منابع مشابه
Cytokine gene transfer in the therapy of autoimmune diseases
Detlef Neumann and Diana Boraschi* Hannover Medical School, Hannover, Germany Institute of Biomedical Technologies, CNR, Pisa, Italy __________________________________________________________________________________ *Correspondence: Diana Boraschi, Laboratory of Cytokines, Unit of Immunobiology, Institute of Biomedical Technologies, Area della Ricerca di S. Cataldo, Via G. Moruzzi 1, I-56124 Pi...
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Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have...
متن کاملNonviral cytokine gene therapy on an orthotopic bladder cancer model.
PURPOSE The purpose is to assess cytokine gene transfection in tumor cells and its therapeutic efficacy in an orthotopic mouse bladder cancer model after liposome-mediated gene transfer. EXPERIMENTAL DESIGN A total of 1 x 10(5) MB49 cells was instilled into the bladder of C57BL/6 mice after electrocautery to establish the tumor model. The plasmids were constructed by inserting the coding sequ...
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Background: Tumor necrosis factor-beta or lymphotoxin-alpha (LT-α), IL-4 and IL-10 are determining factors in immunity against BCG. Allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in BCG containment. Objective: To study the prevalence of –590 (C/T) and –592 (C/A) allelic distribution of IL-4 and IL-10 promo...
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however, suffer from a problem implied by its title. Dr. Schull's attempts to make the book lyrical lead to the sin of vivid writing, often complicated by inappropriate usages. For example, it seems unlikely that the lanes mentioned on page 15 were "tortured"; "tortuous" is more likely. Can sleep come in "dollops" (page 22)? Do physicians actually ride jeeps like "marauding bees" (page 26)? (Ar...
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ژورنال
عنوان ژورنال: STEM CELLS
سال: 2009
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.5530160831